@article{Taheri Mirghaed_Yarahmadi_Shabrang harehdasht_Craig_Ghafari Farsani_Ghysvandi_Eagderi_2018, title={Hemato-immunological, serum metabolite and enzymatic stress response alterations in exposed rainbow trout (Oncorhynchus mykiss) to nanosilver}, volume={6}, url={https://ij-aquaticbiology.com/index.php/ijab/article/view/512}, DOI={10.22034/ijab.v6i4.512}, abstractNote={<p>The aim of present study was to investigate the effects of sub-lethal concentrations of silver nanoparticles (AgNP) on hematological parameters, differential tests of white blood cells, serum metabolite parameters, serum enzymes activity and serum ions in rainbow trout, <em>Oncorhynchus mykiss</em>. Healthy rainbow trout, were exposed to sub-lethal concentrations (0, 1.5 and 2.5 ppm) of nanosilver for 14 days. RBC, WBC and Hct levels were significantly (<em>P</em><0.05) increased in exposed groups. Within the white blood cells, only neutrophils showed a significant increase at 7 and 14 days post exposure (<em>P</em><0.05). Serum triglyceride, total serum protein, albumin and globulin levels were decreased (<em>P</em><0.05) in exposed fish, however, cholesterol levels increased in the 2.5<em> </em>ppm group at 7 days after exposure (<em>P</em><0.05). Cortisol and glucose increased significantly at 7 and 14 days of exposure in both concentrations of AgNPs (<em>P</em><0.05). Decreases in serum ions level were observed, although reduction in chloride ions occurred earlier and more severe than other measured parameters (<em>P</em><0.05). Elevation in serum ALP, LDH, ALT and AST enzymes were observed during the experiment (<em>P</em><0.05), although SOD and CAT activity were significantly decreased in exposed groups (<em>P</em><0.05). The results revealed that AgNP can affect the hematological, serum metabolite and enzymatic parameters of <em>O. mykiss</em>, as well as AgNP exposure induce a general oxidative stress response in <em>O. mykiss.</em></p>}, number={4}, journal={International Journal of Aquatic Biology}, author={Taheri Mirghaed, Ali and Yarahmadi, Peyman and Shabrang harehdasht, Mitra and Craig, Paul M. and Ghafari Farsani, Hamed and Ghysvandi, Nahid and Eagderi, Soheil}, year={2018}, month={Aug.}, pages={221–234} }